In this call for applications, we seek to support research projects that deepen our understanding of the molecular events “downstream of RNA transcription” that diversify gene expression and function in embryonic and early postnatal development of the nervous system. The emphasis is on how these mechanisms contribute to normal nervous system development, physiological homeostasis and/or neural cell function, and how their dysfunction may contribute to neurodevelopmental disorders. Discoveries made possible by this RFA could lead to the development of mechanism-based interventions that address the fundamental molecular features that underlie neurodevelopmental conditions.
Individual or team projects will be funded to a maximum of $150,000 CAD per year for a maximum of three years. We expect to fund the top six applications, as determined by an external peer-review process.
- Post-transcriptional regulation of gene expression, including, for example, (but not limited to): RNA splicing, stability and localization; circular RNA biogenesis and function; regulation of RNAs by miRNA and RNA binding proteins (RBP); composition and role of RNA-associated granules and bodies
- Regulation of protein translation, including (but not limited to): Ribosome elongation, termination and quality control; localization of protein translation; regulation of protein degradation; Phase separation of protein complexes
- Spatial and temporal regulation of the above post-transcriptional/post-translational mechanisms in neuronal development and/or associated neurodevelopmental conditions
We will accept applications using any relevant model/experimental system, provided the focus is relevant to the nervous system.