Remi
Casier

Dr. Remi Casier is an Azrieli International Postdoctoral Fellow in the Department of Chemical and Biological Physics at the Weizmann Institute of Science.

Under the supervision of Prof. Gilad Haran, Remi employs single-molecule spectroscopy to study the ultrafast conformational dynamics of proteins.

Protein disaggregases are molecular machines that reverse protein aggregation, making them a vital component of cells and enabling their use in the development of therapeutics to combat neurodegenerative disorders. Remi aims to apply his background knowledge in polymer physics to study the dynamic interaction between a disaggregase and its substrates and thus enhance our understanding of their disaggregation mechanism on the molecular level.

Born and raised in Canada, Remi obtained his BSc and MSc in chemistry from the University of Waterloo. During his MSc under the supervision of Prof. Mario Gauthier and Prof. Jean Duhamel, Remi began his studies in polymer science developing a new technique to quantify the diffusion of polymer chains during the coalescence of latex films. Continuing with Prof. Duhamel for his PhD studies, Remi shifted his focus to the internal dynamics of biological macromolecules, particularly polypeptides. Employing the relationships he discovered between amino acid composition and local chain dynamics, he developed a blob-based model to provide experimentally supported insight into the complex phenomena of protein folding. When not working on his research, Remi enjoys travelling, spending time in nature, and trekking adventures